MP086PODOCYTES CONTRIBUTE TO CARNITINE HOMEOSTASIS VIA EXPRESSING A CARNITINE EFFLUX TRANSPORTER SLC16A9
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چکیده
منابع مشابه
Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB
Srinivas SR, Prasad PD, Umapathy NS, Ganapathy V, Shekhawat PS. Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB . Am J Physiol Gastrointest Liver Physiol 293: G1046–G1053, 2007. First published September 13, 2007; doi:10.1152/ajpgi.00233.2007.—L-Carnitine is absorbed in the intestinal tract via the carnitine transport...
متن کاملTransport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+).
L-carnitine is absorbed in the intestinal tract via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+). Loss-of-function mutations in OCTN2 may be associated with inflammatory bowel disease (IBD), suggesting a role for carnitine in intestinal/colonic health. In contrast, ATB(0,+) is upregulated in bowel inflammation. Butyrate, a bacterial fermentation product, is beneficial...
متن کاملMutations of OCTN2, an organic cation/carnitine transporter, lead to deficient cellular carnitine uptake in primary carnitine deficiency.
Systemic primary carnitine deficiency (CDSP, OMIM 212140) is an autosomal recessive disease characterized by low serum and intracellular concentrations of carnitine. CDSP may present with acute metabolic derangement simulating Reye's syndrome within the first 2 years of life. After 3 years of age, patients with CDSP may present with cardiomyopathy and muscle weakness. A linkage with D5S436 in 5...
متن کاملMetabolic flexibility and carnitine flux: The role of carnitine acyltransferase in glucose homeostasis
Skeletal muscle is the major site of glucose disposal, accounting for 80% of glucose catabolism under insulin-stimulated conditions in healthy subjects. In type 2 diabetes mellitus patients, muscular glucose uptake is decreased; therefore, skeletal muscle can be a major therapeutic target for the daily control of hyperglycemia and improvement in insulin sensitivity. To develop therapeutic appro...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2017
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfx162.mp086